Winback and collagen are intimately linked, whether during wound healing or to restart a synthesis process in case of fibrosis. But through which processes does Winback act on collagen?

What is collagen?

Collagen is the structural protein present in all vertebrates. It is the most abundant protein, since we find it in all extra-cellular matrices. In fact, it represents 30% of total proteins in mammals. Collagen is synthesized by cells of mesenchymal origin. The fibroblast is the key cell, which will differentiate according to certain tissue specificities (odontoblast, osteoblast, etc…).

The first steps of procollagen synthesis are intracellular. This procollagen is secreted into the extra-cellular matrix by exocytosis, where it is assembled into protocollagen, to create by cross-linking the different collagen fibers. Depending on their shape, their microscopic structure and their mechanical resistance, the different fiber assemblies will give more than twenty different types of collagen.

Type I collagen present in particular in bones, dermis, tendons, ligaments, represents 60 to 80% of collagens. Type III collagen, also very important, is observed at the dermal-epidermal junction and the basal lamina of blood vessels, nerves and adipocytes.

During pathologies, lesions, or following inflammation or scarring, collagen undergoes a reworking in its assembly and in the composition of the different types. Collagen has a variable lifespan depending on the tissue, from 2 months for the dermis to several years for bone tissue, in fact, it degrades under the effect of several enzymes. In addition, it is denatured under the action of heat.

The Collagen-Winback link

The Winback technology will therefore act in 2 important steps of collagen synthesis and remodeling. First, membrane depolarization, created by the passage of current, will allow a better exocytosis of procollagen, making it more easily bioavailable. And diathermy will induce a denaturation of the collagen which will allow its subsequent reworking.

We then understand the interest of the Winback technology on all tissues containing collagen, i.e. all connective tissues. Thus, the applications will be multiple, as much in rehabilitation, in order to optimize the remodeling of collagen fibers, for muscular or tendinous pathologies, as for the treatment of scars. In Beauty, the action will be identical on the dermis, in particular with these Anti-aging protocols.